A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.
نویسندگان
چکیده
منابع مشابه
Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene.
Prophet of Pit-1 (Prop1) is a transcription factor that regulates Pit-1 gene expression. Because Pit-1 regulates the differentiation of pituitary cells and the expressions of GH, prolactin and TSHbeta genes, Prop1 mutation results in combined pituitary hormone deficiency in humans. However, Prop1-binding sites in human Pit-1 gene and the mechanism leading to combined pituitary hormone deficienc...
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The Des Moines Lobe was the largest of several lobes of the Laurentide Ice Sheet that extended into the mid-continent region of North America near the end of the last glaciation. At its maximum extent, ~13,800 radiocarbon years ago, the lobe was up to 250 km wide and covered greater than 10 km in southern Minnesota and north-central Iowa (Fig. 1). The lobe deposited diverse sediments, but only ...
متن کاملInteraction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression.
The pituitary-specific, POU-homeodomain factor GHF-1/Pit-1 is necessary, but not sufficient, for cell-specific expression of prolactin (PRL), growth hormone (GH), and thyrotropin. Combinatorial interactions of GHF-1 with other factors are likely to be required; however, such factors and their mechanisms of action remain to be elucidated. Here we identify Ets-1 as a factor that functionally and ...
متن کاملPituitary-specific expression and Pit-1 regulation of the rat growth hormone-releasing hormone receptor gene.
The GHRH receptor is expressed in the somatotroph cell of the anterior pituitary, where it functions to mediate GHRH-stimulated GH release. To study pituitary and somatotroph cell-specific expression of this gene, a transgenic mouse model and complementary cell culture experiments were developed. The activity of the 1.6-kb proximal rat GHRH receptor promoter was examined in vivo by generating t...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1993
ISSN: 0890-9369
DOI: 10.1101/gad.7.6.913